The likes of Phil Jones, Marcos Rojo and Matteo Darmian have managed to force their way back into the fold due to injuries in defence.
But Memphis Depay, Morgan Schneiderlin and Ashley Young have regularly been on the sidelines and at times left out of match day squads.
Reports suggest Mourinho is willing to let Manchester United duo Depay and Schneiderlin leave in January for first-team football.
And Mourinho says being "overbooked" in some positions has hurt their chances.
He told Sky Sports: "I still have some bad feelings towards myself because I didn't give a real chance to everyone, there are some positions in our squad where we have overbooked.
"To be honest, people like Ashley Young and Memphis Depay, I didn't really give them a run of matches to play, to prove. So I have this little bad feeling.
"In relation to Marcos and Phil Jones, I'm really pleased with both.
"Marcos, he was a player considered by many as someone without the quality to be a Manchester United player.
"Phil was [seen as] a stampede, injury-prone player without the conditions to be back to the good Phil Jones of the past, so I was very happy for them."
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